Authors: Frank Verhoeven, Pieter Ravensbergen, Imco Sibum, Bernhard Müllinger, Nicolas A. Buchmann
Event: DDL 2024, 11 – 13 December 2024, Edinburgh, United Kingdom
Abstract: The nasal administration route has garnered substantial interest for vaccination and nose-to-brain delivery via the olfactory region.
Current swirl nozzle devices deliver less than 5-10% of their dose to the target region. A novel pre-filled syringe soft mist nasal spray delivers over 40% to the olfactory region, significantly improving delivery efficiency for nose to brain applications, with the ability to target regions of interest for nasal vaccines, such as the posterior nasal cavity.
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