Influence of fluid physiochemical properties on aerosolisation performance of a novel soft mist inhaler

Authors: Varsha Komalla, Imco Sibum, Bernhard Muellinger, Wietze Nijdam, Vishal Chaugule, Julio Soria, Nicolas Buchmann, Hui Xin Ong, D. Traini

Event: DDL 2023, 6 – 8 December 2023, Edinburgh, United Kingdom

Abstract: Soft mist inhalers (SMIs) are propellant-free inhalers that are gaining interest in the delivery of drugs, especially proteins and biologics, due to the low shear stress they produce during aerosolisation and low carbon footprint. The effectiveness of the SMI inhalation therapy relies on many factors, including the device manufacture and physicochemical properties of the inhalation solution.

The Aim of the study was to evaluate the influence of fluid physiochemical properties on droplet size distribution using the Pulmospray™ SMI device, (Resyca B.V, Enschede, Netherlands).

Specifically, we will evaluate the following properties: fluid viscosities, ionic strength and surface tension of different fluid mixtures and study their particle size distribution at two different inhalation flow rates.

In conclusion, the single-use Pulmospray™ SMI device is an efficient inhaler for the delivery of drug products to the lungs with varying physiochemical properties of the inhalation solution and inspiratory flow rates.